白宫报告呼吁对"僵化"的美国科学体系进行重大改革
White House report calls for big changes to ‘calcified’ U.S. science system
特朗普政府科学顾问迈克尔·克拉齐奥斯今天在国会面对这些提议的批评者
In Congress today, Trump science adviser Michael Kratsios faced critics of the proposals
每日自动采集 Science、Nature 官方渠道的最新文章标题与摘要,并翻译为中文。
更新日期 · 2026-07-23 · 共 63 条
White House report calls for big changes to ‘calcified’ U.S. science system
特朗普政府科学顾问迈克尔·克拉齐奥斯今天在国会面对这些提议的批评者
In Congress today, Trump science adviser Michael Kratsios faced critics of the proposals
Contagious fish cancer overruns New England lake
基因研究显示,鲶鱼黑色素瘤是鱼类中首例可传染的癌症
Catfish melanomas are the first example of a transmissible cancer in fish, genetic studies reveal
Chimps and bonobos hug and hold hands just like us
新研究表明,类人猿之间安抚性的社会接触具有古老的起源
New study suggests ancient origins of reassuring social touch among apes
Rapid spread of Ebola spurs ‘remarkably’ quick drug and vaccine trials
开创性研究正在开展,以应对刚果境内罕见本迪布焦病毒的大规模暴发
Pioneering studies are underway to address massive outbreak of rare Bundibugyo virus in the Congo
Earth’s core may be far cooler than scientists thought
新的测量结果或许有助于解释这颗行星的磁发电机为何能持续运行数十亿年
New measurements could help explain how the planet’s magnetic dynamo churned for billions of years
U.S. judge rejects Trump’s justification for terminating thousands of grants
各州对此裁定表示欢迎,但白宫仍可能寻求其他方式终止相关经费
States hail decision, but White House may try other ways to end funding
Scientists attack ban on adding ‘noise’ to U.S. census data and many surveys
批评者指出,特朗普的真正目的是在2030年人口普查中制造疑云,并为共和党在国会增加席位
Critics say Trump’s real goal is to sow doubts about 2030 census and add Republican seats in Congress
Goats love to bash heads—but it might give them brain damage
三只用头对撞的山山山……不对,三只相互对撞的山羊出现了与人类头部外伤后相似的神经退行性病变
Three headbutting goats showed signs of neurodegeneration similar to those in humans following head injuries
Trump administration ends dozens of grants for studying patient care
“不予资助”通知终止了美国医疗保健研究与质量局(AHRQ)多项年度经费本就处于停滞状态的资助项目
“Nonaward” notices discontinue grants from the Agency for Healthcare Research and Quality whose annual funds had been stalled
China’s detention of U.S. seismologist and data-sharing crackdown alarm researchers
Youlin Chen(陈友林)所分析的地震数据也可用于核试验监测
Youlin Chen analyzed earthquake data that can also aid nuclear-test monitoring
Cross-cohort analysis of expression and splicing quantitative trait loci in TOPMed
《Science》第393卷第6808期,2026年7月。
Science, Volume 393, Issue 6808, July 2026.
Surface-dominant transport in Weyl semimetal NbAs nanowires for next-generation interconnects
《Science》第393卷第6808期,第272–279页,2026年7月。
Science, Volume 393, Issue 6808, Page 272-279, July 2026.
A transcriptional biosensor reveals mechanisms of α-ketoglutarate signaling to chromatin
《Science》第393卷第6808期,2026年7月。
Science, Volume 393, Issue 6808, July 2026.
Direct interaction of Vδ7 TCRs with IL17RA drives the differentiation of TH1-like γδT cells
《Science》第393卷第6808期,2026年7月。
Science, Volume 393, Issue 6808, July 2026.
Production and spectroscopy of cold radioactive molecules
《Science》第393卷第6808期,第319–323页,2026年7月。
Science, Volume 393, Issue 6808, Page 319-323, July 2026.
Drying of the Aral Sea reshapes the anthropogenic carbon inventory of Central Asia
《Science》第393卷第6808期,第300–305页,2026年7月。
Science, Volume 393, Issue 6808, Page 300-305, July 2026.
Tracing the origins of St Helena’s liberated Africans
《Science》,第 393 卷,第 6808 期,2026 年 7 月。
Science, Volume 393, Issue 6808, July 2026.
Cyclic sealing and drainage on an oceanic transform fault
《Science》,第 393 卷,第 6808 期,2026 年 7 月。
Science, Volume 393, Issue 6808, July 2026.
Geometrically driven reversible solid-liquid phase transition at the atomic scale
《Science》,第 393 卷,第 6808 期,第 280–286 页,2026 年 7 月。
Science, Volume 393, Issue 6808, Page 280-286, July 2026.
Structure and evolution-guided design of minimal RNA-guided nucleases
《Science》,第 393 卷,第 6808 期,第 313–318 页,2026 年 7 月。
Science, Volume 393, Issue 6808, Page 313-318, July 2026.
Performance trade-offs define a fundamental dental dichotomy in mammals
《Science》,第 393 卷,第 6808 期,第 265–271 页,2026 年 7 月。
Science, Volume 393, Issue 6808, Page 265-271, July 2026.
Spatiotemporally homogeneous crystallization for ambient scalable perovskite photovoltaics
《Science》,第 393 卷,第 6808 期,第 287–293 页,2026 年 7 月。
Science, Volume 393, Issue 6808, Page 287-293, July 2026.
Parallel independent voltage computing along dendrites of CA3 pyramidal neurons
《Science》,第 393 卷,第 6808 期,第 306–312 页,2026 年 7 月。
Science, Volume 393, Issue 6808, Page 306-312, July 2026.
Robust single-electron memory with quantum states manipulation
《Science》,第 393 卷,第 6808 期,第 294–299 页,2026 年 7 月。
Science, Volume 393, Issue 6808, Page 294-299, July 2026.
Restored clearance of senescent neutrophils by tissue-resident macrophages limits organ aging
《Science》,第 393 卷,第 6808 期,2026 年 7 月。
Science, Volume 393, Issue 6808, July 2026.
Could small-team science be dying out?
Breathalyser can tell if you are burning fat from a single exhale
Electronic-resonance enhanced molecule for perovskite solar cells
RNA synthesis and substrate analog inhibition in the CCHFV polymerase
What counts as a moon? Huge ‘exosatellite’ sparks debate
How do quantum computers work?
Structures and inhibition of the Crimean–Congo haemorrhagic fever virus polymerase
CRISPR–Cas regulates expression of embedded anti-phage defence systems
Non-epitaxial perovskite polariton laser diode operating under direct current
Prior therapy defines mutation profiles in childhood cancer at relapse
Structural basis of the RNA-editing cascade in trypanosome mitochondria
Insulator-free topological photonic multi-lane highways
Planetary-mass exosatellite detected around the substellar companion of a star
Tertiary lymphoid structures harbour stem-like tumour-specific T cells
A vector-based strategy for olfactory navigation in Drosophila
Advancing science by designing for surprise
Recovering lost origins
综合证据有助于三角验证埋葬在圣赫勒拿岛的非洲奴隶的来源
Integrated evidence helps triangulate the origins of African slaves buried on St Helena
The rise and fall of the Amazon Soy Moratorium
这项自愿性零毁林协议面临的挑战可能会给森林和大豆行业带来代价
Challenges to the voluntary zero-deforestation pact could impose costs for forests and the soy sector
AI in scientific publishing: Slower, worse, and more expensive
管理学界有一句广为流传的话,由20世纪90年代美国国家航空航天局(NASA)局长丹尼尔·戈尔丁所推崇,即技术进步的目标是使产品更快、更好、更便宜。尽管这一策略在航空航天业取得了一定成效,但人工智能(AI)的狂热支持者也在用同样的论据来宣扬它将如何改变工作方式,声称所需的人力投入将如此之少,以至于人类将进入一个远离疾病、辛劳和危险等的富足时代,从而为社会留下更多时间用于创造性追求
There’s a saying in the management world, popularized by NASA administrator Daniel Goldin in the 1990s, that the goal of technological improvements is to make products faster, better, and cheaper. Although this strategy had some success in the aerospace industry, the zealots of artificial intelligence (AI) have been making the same argument regarding how it will transform work, claiming that so little human effort will be required that humanity will enter an era of radical abundance, free from disease, drudgery, and danger, among other benefits, leaving society with more time for creative purs
Scandinavian radar array will probe mysteries of the aurora
EISCAT_3D将在太阳爆发搅动高层大气时绘制出一幅全新的图景
EISCAT_3D will paint a new picture of the upper atmosphere as it is roiled by solar outbursts
U.S. researchers express outrage over proposed changes to managing federal grants
白宫收到34万条针对规则的评论,许多人担心这些规则将使科学政治化
White House receives 340,000 comments on rules many fear would politicize science
A cinnamyl alcohol dehydrogenase–like scaffold organizes monoterpenoid indole alkaloid biosynthesis
约3000种单萜吲哚生物碱(MIAs)的生物合成,包括抗癌药物长春碱,涉及高度不稳定中间体异胡豆苷糖苷配基的生成。该中间体由异胡豆苷β-葡萄糖苷酶(SGD)生成,随后由蛇根精合成酶(GS)转化,这些过程发生在空间分隔的区室中,构成生物合成的主要瓶颈。本研究发现了VinBLAST,一种被重新利用作为支架的类肉桂醇脱氢酶蛋白,可高效处理该不稳定中间体。VinBLAST在物理上介导SGD和GS在细胞核中的相互作用并发挥别构调控作用
Biosynthesis of ~3,000 monoterpenoid indole alkaloids (MIAs), including the anticancer drug vinblastine, involves the highly unstable intermediate strictosidine aglycone. Its formation by strictosidine β-glucosidase (SGD) and subsequent conversion by geissoschizine synthase (GS) occur in spatially separated compartments, representing a major biosynthesis bottleneck. Here we discover VinBLAST, a cinnamyl alcohol dehydrogenase–like protein repurposed as a scaffold for efficient processing of this labile intermediate. VinBLAST physically mediates SGD and GS interaction in the nucleus and alloster
In Other Journals
编辑从当前科学文献中遴选的精彩内容
Editors’ selections from the current scientific literature
In Science Journals
《科学》系列期刊的精彩集锦
Highlights from the Science family of journals
As the Arctic warms, gray whale boom turns into a bust
科学家指出,种种变化正威胁这些海洋哺乳动物至关重要的觅食地
Scientists point to changes that jeopardize the marine mammals’ critical feeding grounds
Lymph nodes now optional
一类树突状细胞主导了肿瘤组织内三级淋巴结构的形成
A subset of dendritic cells orchestrates the formation of tertiary lymphoid structures in tumor tissues
Regional drivers and contributors to changes in life expectancy across Asia
A global molecular code for birth order and neuronal identity in Drosophila
功能性神经环路的组装依赖于具有精确分子身份与连接性的多样化神经元的产生。要揭示整个神经系统中神经元特化与布线的一般规律,需要对其多样性进行系统且高分辨率的刻画,近年来单细胞转录组学与连接组学的进展使这一目标成为可能。然而,将神经元的分子身份与环路结构联系起来仍是一项关键挑战。本研究构建了黑腹果蝇的高分辨率发育转录组图谱
Abstract The assembly of functional neural circuits relies on the generation of diverse neural types with precise molecular identity and connectivity. Unlocking general principles of neuronal specification and wiring across the nervous system requires a systematic and high-resolution characterization of its diversity, recently enabled by advances in single-cell transcriptomics and connectomics. However, linking the molecular identity of neurons to circuit architecture remains a key challenge. Here we present a high-resolution developmental transcriptional atlas for the Drosophila melanogaster
Precise DNA base editing using AlphaFold3-based contact modelling
AI identifies interactions in CRISPR complexes to improve specificity of DNA editing
Polio should have been eradicated by now. What’s plan B?
Fly neurons carry a molecular ‘timestamp’ that encodes their birth order
Three tips to avoid AI image mistakes in science
AI-redesigned starting points and outcomes enhance protein evolution
工程化或实验室进化所得的蛋白质往往在稳定性、活性或特异性方面存在不足。本研究将基于人工智能(AI)的蛋白质序列设计方法应用于实验性酶进化,以应对相关挑战。我们利用 ProteinMPNN 模型重新设计了三种不同的肉毒神经毒素(BoNT)蛋白酶,所生成的变体具有更高的稳定性并保持了完全的催化效率。我们假设,经重新设计的酶可能比其野生型(WT)对应物具有更高的突变稳健性,因此可作为进化新功能的更优起点。
Abstract Engineered or laboratory-evolved proteins often have suboptimal stability, activity or specificity. Here we applied artificial intelligence (AI)-based protein sequence design to address challenges in experimental enzyme evolution. Using the model ProteinMPNN, we redesigned three distinct botulinum neurotoxin (BoNT) proteases, generating variants with improved stability and full catalytic efficiency 1 . We hypothesized that redesigned enzymes may be more mutationally robust than their wild-type (WT) counterparts, and therefore may serve as better starting points to evolve new function.
Semiconducting and magnetic lanthanide MXenes from intercalated halides
The planktonic microbiome of the Great Barrier Reef
大型基因组数据库已显著提升了我们对海洋微生物的理解。尽管这些资源主要聚焦于原核生物,但许多海洋优势谱系(如 Pelagibacter 和 Prochlorococcus)的基因组仍明显代表性不足。本研究构建了大堡礁微生物基因组数据库(GBR-MGD),其包含通过 Nanopore 与 Illumina 测序技术从大堡礁海水样本中获得的 5,283 个原核生物基因组,并囊括了一组此前代表性不足类群的高质量基因组。我们发现,标准的短读长组装
Abstract Large genome databases have markedly improved our understanding of marine microorganisms 1–5 . Although these resources have focused on prokaryotes, genomes from many dominant marine lineages, such as Pelagibacter and Prochlorococcus , are conspicuously underrepresented. Here we present the Great Barrier Reef Microbial Genomes Database (GBR-MGD), comprising 5,283 prokaryotic genomes obtained from Great Barrier Reef seawater samples using Nanopore and Illumina sequencing, including a collection of high-quality genomes of underrepresented groups. We show that standard short-read assembl
Non-Gaussian statistics of the order parameter across a phase transition
‘Good design takes mastery’: scientific illustrators sketch out AI’s future